Endocrine Abstracts

Obestatin (Ob) is a peptide recently identified as a product of the ghrelin gene. It was claimed to bind to the orphan receptor GPR39, but this finding is still a matter of debate. Ob exerts peripheral effects, for example, it promotes cell survival and has antiapoptotic actions in different cell lines. In addition, Ob has central effects, such as inhibition of thirst, modulation of anxiety, sleep and mnemonic functions. Mnemonic processes involve neurogenesis; in particular, ...